The current era is witnessing serious geopolitical changes during the Arab spring and its waves in the Arab countries specifically. This geopolitics change is reflecting serious geostrategic changes on the OIC (Organization of Islamic Countries) as well, which causes serious impacts on all OIC internally and externally. Under the forum theme “Unity in diversity: Source of power”, the paper introduces some crucial geostrategic concepts to develop common national and regional understanding in order to avoid geostrategic confrontation, and to exploit the strategic opportunities. The paper calls for geostrategic interests’ integration management, and for reaching the point of geostrategic equilibrium so as to start developing, what is called by the writer, geostrategic regional initiatives. This paper will propose crucial strategic imperatives within the context of the complex dynamic of the Arab spring’s transitional period and its impact on the region in order to support the unity of the OIC countries in this dilemma.